Joint modelling of colorectal cancer recurrence and death after resection using multi-state model with cured fraction

Abstract Curing of colorectal cancer (CRC) occurs at the time resection but it is not immediately observable. If completely eliminated, patient will be cured and experience recurrence as tumor has regrown to a detectable size. The main propose present study was assess effects different covariates on probability being well time-to-recurrence, time-to-death in CRC patients by using multi-state cure model. information 283 with CRC, who underwent resection, from 2000 2015 Imam Khomeini Hospital Hamadan, Iran, were analyzed. results model reveal that females metastasis more likely apparently cured. It been shown sex significant effect time-to-recurrence given group. survival group affected stage disease. However, age diagnosis status. provided flexible framework prognostic factors simultaneously transition between states CRC.